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KMID : 1161520110150030203
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Animal Cells and Systems
2011 Volume.15 No. 3 p.203 ~ p.210
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Expression of pro-opiomelanocortin and agouti-related protein in the hypothalamus of caffeine-administered rats
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Jeong Joo-Yeon
Ku Bo-Mi
Lee Yeon-Kyung
Ryu Jin-Hyun
Choi Jung-Il
Kim Joon-Soo
Cho Yong-Woon
Roh Gu-Seob
Kim Hyun-Joon
Cho Gyeong-Jae
Choi Wan-Sung
Kang Sang-Soo
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Abstract
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In the present study, we examined the effects of caffeine on food intake and body weight, and pro-opiomelanocortin (POMC) and agouti-related protein (AgRP) expression in the hypothalamus. Rats were administered intraperitoneally with 100 mg/kg caffeine (a high, non-toxic dose) or saline during the light phase. Intraperitoneal administration of caffeine induced a significant reduction in food intake and body weight 12 hr after treatment. In addition, POMC expression was significantly increased and AgRP expression was decreased in the arcuate nucleus (Arc) after caffeine treatment. These results demonstrate that administration of caffeine up-regulates POMC expression and down-regulates AgRP expression in the Arc, suggesting that the activation of the hypothalamic POMC neurons and inhibition of the AgRP neurons might play a role in the regulation of food intake and body weight by caffeine.
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KEYWORD
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body weight, food intake, POMC, AgRP, caffeine
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